These include its response to sum-of-sines stimuli, its response after lesions of the nucleus prepositus hypoglossi or the flocculus, characteristics of VOR adaptation, and characteristics of drift in the dark. In addition to our own data, we also reproduced the behavior of the compensatory eye movement system found in the existing literature. Most importantly, it could explain the interaction of VOR and OKR when the two reflexes are activated simultaneously during vVOR stimulation. The model successfully reproduced the eye movements in all conditions, except for minor failures to predict phase when gain was very low. The conditions included vestibular stimulation in the dark (vestibular-ocular reflex, VOR), optokinetic stimulation (optokinetic reflex, OKR), and two combined visual/vestibular conditions (the visual-vestibular ocular reflex, vVOR, and visual suppression of the VOR, sVOR). We challenge the model with a data set of eye movements in mice ( n =34) recorded in 4 different sinusoidal stimulus conditions with 36 different combinations of frequency (0.1–3.2 Hz) and amplitude (0.5–8°) in each condition.
We present a working model of the compensatory eye movement system in mice. 7ABC Centre for Robotics, Ben Gurion University, Beer-Sheva, Israel.6Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.5Department of Experimental and Applied Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.4Singapore Institute for Neurotechnology, Singapore, Singapore.3School of Psychology, University of Birmingham, Birmingham, United Kingdom.2Department of Biomedical Engineering, Zlotowski Centre for Neuroscience, Ben Gurion University, Beer-Sheva, Israel.1Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands.Sibindi 1,2,4 †, Marik Ginzburg 2 †, Suman Das 1,2, Kiki Arkesteijn 1,5,6, Maarten A.